Stadium: Lambeau Field Round: 203
Home Manager: Kyle Shanahan Away Manager: Matt LaFleur
| NFL | 2021/09/27 00:20 | GB Packers v SF 49ers | L | 30-28 |
| NFL | 2020/11/06 01:20 | GB Packers v SF 49ers | L | 34-17 |
| NFL | 2020/01/19 23:40 | GB Packers v SF 49ers | W | 20-37 |
| NFL | 2019/11/25 01:20 | GB Packers v SF 49ers | W | 8-37 |
| NFL | 2018/10/16 00:15 | SF 49ers v GB Packers | L | 30-33 |
| NFL Preseason | 2016/08/27 02:00 | SF 49ers v GB Packers | L | 10-21 |
| NFL | 2015/10/04 20:25 | SF 49ers v GB Packers | L | 3-17 |
| NFL | 2021/10/25 00:20 | IND Colts v SF 49ers | L | 30-18 |
| NFL | 2021/10/10 20:25 | SF 49ers v ARZ Cardinals | L | 10-17 |
| NFL | 2021/10/03 20:05 | SEA Seahawks v SF 49ers | L | 28-21 |
| NFL | 2021/09/27 00:20 | GB Packers v SF 49ers | L | 30-28 |
| NFL | 2021/09/19 17:00 | SF 49ers v PHI Eagles | W | 17-11 |
| NFL | 2021/09/12 17:00 | SF 49ers v DET Lions | W | 41-33 |
| NFL Preseason | 2021/08/29 20:00 | LV Raiders v SF 49ers | W | 10-34 |
| NFL Preseason | 2021/08/22 23:30 | SF 49ers v LA Chargers | W | 15-10 |
| NFL | 2021/10/24 17:00 | WAS Commanders v GB Packers | W | 10-24 |
| NFL | 2021/10/17 17:00 | GB Packers v CHI Bears | W | 24-14 |
| NFL | 2021/10/10 17:00 | GB Packers v CIN Bengals | W | 25-22 |
| NFL | 2021/10/03 20:25 | PIT Steelers v GB Packers | W | 17-27 |
| NFL | 2021/09/27 00:20 | GB Packers v SF 49ers | W | 30-28 |
| NFL | 2021/09/21 00:15 | DET Lions v GB Packers | W | 17-35 |
| NFL | 2021/09/12 20:25 | GB Packers v NO Saints | L | 3-38 |
| NFL Preseason | 2021/08/28 17:00 | GB Packers v BUF Bills | L | 0-19 |