Stadium: Levi's Stadium Round: 1
Home Manager: Pete Carroll Away Manager: Kyle Shanahan
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 0 | 7 | 7 | 14 | 7 | 28 |
| 7 | 0 | 7 | 6 | 8 | 21 |
| SEA Seahawks | SF 49ers |
| Lineup | |
|---|---|
| 89 - TE - Will Dissly | Richie James - WR - 13 |
| 36 - DB - Blessuan Austin | Samson Ebukam - DL - 56 |
| 2 - DB - D.J. Reed | George Kittle - TE - 85 |
| 57 - Left back - Cody Barton | D.J. Jones - DT - 93 |
| 14 - WR - DK Metcalf | Kerryon Johnson - Right back - 48 |
| 59 - Left back - Jon Rhattigan | Taybor Pepper - LS - 46 |
| 74 - OT - Jake Curhan | Jake Brendel - OL - 64 |
| 18 - WR - Freddie Swain | Emmanuel Moseley - DB - 41 |
| 52 - DE - Darrell Taylor | Javon Kinlaw - DT - 99 |
| 84 - TE - Colby Parkinson | Dee Ford - DE - 55 |
| 68 - Guard - Damien Lewis | Deebo Samuel - WR - 19 |
| 56 - Left back - Jordyn Brooks | Trenton Cannon - Right back - 49 |
| 64 - OG - Dakoda Shepley | Talanoa Hufanga - SAF - 29 |
| 98 - DL - Alton Ledell Robinson | Ross Dwelley - TE - 82 |
| 31 - ATH - DeeJay Dallas | Deommodore Lenoir - DB - 2 |
| 27 - DB - Marquise Blair | Azeez Al-Shaair - Left back - 51 |
| 11 - WR - Cody Thompson | Arden Key - Left back - 98 |
| 21 - SAF - Tre Flowers | Fred Warner - Left back - 54 |
| 4 - Pivot - Michael Dickson | Demetrius Flannigan-Fowles - SAF - 45 |
| 92 - DT - Robert Nkemdiche | Kentavius Street - DE - 95 |
| 5 - K - Jason Myers | Mike McGlinchey - OL - 69 |
| 69 - - Tyler Ott | Marcell Harris - DB - 36 |
| 6 - Center back - Quandre Diggs | Daniel Brunskill - TE - 60 |
| 54 - Left back - Bobby Wagner | Nick Bosa - DL - 97 |
| 16 - WR - Tyler Lockett | Dontae Johnson - Center back - 27 |
| 70 - OL - Cedric Ogbuehi | Charlie Woerner - TE - 89 |
| 3 - QB - Russell Wilson | Trent Sherfield - WR - 81 |
| 66 - OL - Gabe Jackson | Jimmie Ward - SAF - 1 |
| 51 - DL - Kerry Hyder | Buster Skrine - Center back - 41 |
| 76 - OT - Duane Brown | Trey Sermon - Right back - 28 |
| - DE - Carlos Dunlap | Kyle Juszczyk - FB - 44 |
| 41 - Right back - Alex Collins | Tom Compton - OL - 66 |
| 33 - SAF - Jamal Adams | Mitch Wishnowsky - Pivot - 18 |
| 97 - DT - Poona Ford | Dre Kirkpatrick - Center back - 13 |
| 90 - DL - Bryan Mone | Jimmy Garoppolo - QB - 10 |
| 25 - Right back - Travis Homer | Jaylon Moore - OL - 76 |
| 78 - OL - Stone Forsythe | Tavon Wilson - DB - 32 |
| 19 - WR - Penny Hart | Mohamed Sanu - WR - 6 |
| 26 - SAF - Ryan Neal | Jauan Jennings - WR - 15 |
| 99 - DT - Al Woods | Brandon Aiyuk - WR - 11 |
| 28 - SAF - Ugo Amadi | Laken Tomlinson - OG - 75 |
| 94 - DT - Rasheem Green | Trey Lance - QB - 5 |
| 32 - Right back - Chris Carson | Arik Armstead - DL - 91 |
| 61 - Center - Kyle Fuller | Ambry Thomas - Center back - 20 |
| 23 - DB - Sidney Jones | Alex Mack - Center - 50 |
| 44 - Left back - Nick Bellore | Trent Williams - OL - 71 |
| Substitutes | |