Stadium: Carl W. Burt Memorial Stadium Round: 1
| NCAAF | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | L | 48-14 |
| NCAAF | 2021/10/23 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 14-57 |
| NCAAF | 2019/09/28 17:30 | Manchester Spartans v Rose Hulman Engineers | L | 35-52 |
| NCAAF | 2018/09/22 23:00 | Rose Hulman Engineers v Manchester Spartans | L | 19-12 |
| NCAAF | 2022/11/12 18:30 | Anderson Ravens v Manchester Spartans | L | 19-12 |
| NCAAF | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | L | 24-21 |
| NCAAF | 2022/10/29 17:30 | Manchester Spartans v Franklin College Grizzlies | L | 6-24 |
| NCAAF | 2022/10/22 17:30 | Manchester Spartans v Bluffton Beavers | L | 44-46 |
| NCAAF | 2022/10/15 17:30 | Manchester Spartans v Hanover | L | 20-51 |
| NCAAF | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | L | 48-14 |
| NCAAF | 2022/10/01 17:30 | Manchester Spartans v Mount St. Joseph Lions | L | 20-55 |
| NCAAF | 2022/09/17 18:00 | Greenville Panthers v Manchester Spartans | L | 49-22 |
| NCAAF | 2022/11/12 18:30 | Mount St. Joseph Lions v Rose Hulman Engineers | L | 40-31 |
| NCAAF | 2022/11/05 18:00 | Hanover v Rose Hulman Engineers | W | 17-47 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | W | 76-35 |
| NCAAF | 2022/10/22 17:30 | Rose Hulman Engineers v Franklin College Grizzlies | W | 49-0 |
| NCAAF | 2022/10/15 17:30 | Bluffton Beavers v Rose Hulman Engineers | W | 20-48 |
| NCAAF | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | W | 48-14 |
| NCAAF | 2022/10/01 17:30 | Anderson Ravens v Rose Hulman Engineers | W | 7-45 |
| NCAAF | 2022/09/17 16:00 | Rose Hulman Engineers v Albion Britons | L | 17-49 |