Stadium: Joseph J. Gentile Center
Home Manager: Vanessa Blair-Lewis Away Manager: Allison Guth
| WNCAAB | 2022/03/04 00:30 | George Mason (W) v Fordham (W) | L | 50-66 |
| WNCAAB | 2022/03/02 21:00 | Saint Louis (W) v George Mason (W) | W | 50-65 |
| WNCAAB | 2022/02/26 17:00 | George Mason (W) v St Bonaventure Women | W | 61-50 |
| WNCAAB | 2022/02/24 00:00 | Saint Louis (W) v George Mason (W) | L | 58-35 |
| WNCAAB | 2022/02/19 20:00 | VA Commonwealth (W) v George Mason (W) | L | 67-56 |
| WNCAAB | 2022/02/17 00:00 | George Mason (W) v George Washington Women | L | 57-65 |
| WNCAAB | 2022/02/13 20:00 | Saint Joseph's (W) v George Mason (W) | L | 50-45 |
| WNCAAB | 2022/02/11 17:00 | George Mason (W) v Massachusetts (W) | L | 58-87 |
| WNCAAB | 2022/03/11 20:30 | Loyola Chicago (W) v Illinois State (W) | L | 52-68 |
| WNCAAB | 2022/03/05 19:00 | Missouri State Women v Loyola Chicago (W) | W | 42-60 |
| WNCAAB | 2022/03/04 00:00 | Southern Illinois (W) v Loyola Chicago (W) | L | 51-28 |
| WNCAAB | 2022/02/26 00:00 | Loyola Chicago (W) v Valparaiso Women | W | 66-52 |
| WNCAAB | 2022/02/20 19:00 | Loyola Chicago (W) v Evansville (W) | W | 60-56 |
| WNCAAB | 2022/02/18 23:00 | Loyola Chicago (W) v Indiana State (W) | W | 61-59 |
| WNCAAB | 2022/02/15 23:00 | Indiana State (W) v Loyola Chicago (W) | W | 40-64 |
| WNCAAB | 2022/02/12 19:00 | Bradley Women v Loyola Chicago (W) | W | 41-56 |