Stadium: The Buc Dome
Home Manager: Jason Williams Away Manager: Clarisse Garcia
| WNCAAB | 2022/01/22 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 53-55 |
| WNCAAB | 2021/03/06 19:00 | USC Upstate (W) v Charleston Southern (W) | W | 72-64 |
| WNCAAB | 2020/02/12 00:00 | Charleston Southern (W) v USC Upstate (W) | W | 64-71 |
| WNCAAB | 2019/12/28 19:00 | USC Upstate (W) v Charleston Southern (W) | W | 70-53 |
| WNCAAB | 2019/03/12 23:00 | Charleston Southern (W) v USC Upstate (W) | L | 67-52 |
| WNCAAB | 2019/02/09 20:00 | Charleston Southern (W) v USC Upstate (W) | L | 74-62 |
| WNCAAB | 2019/01/19 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 75-78 |
| WNCAAB | 2022/03/04 01:00 | UNC Asheville Women v USC Upstate (W) | L | 62-57 |
| WNCAAB | 2022/02/26 18:00 | USC Upstate (W) v North Carolina A&T (W) | W | 74-63 |
| WNCAAB | 2022/02/23 23:00 | Longwood (W) v USC Upstate (W) | L | 71-66 |
| WNCAAB | 2022/02/19 19:00 | USC Upstate (W) v UNC Asheville Women | W | 68-57 |
| WNCAAB | 2022/02/16 23:00 | USC Upstate (W) v Presbyterian (W) | W | 80-67 |
| WNCAAB | 2022/02/15 23:00 | Presbyterian (W) v USC Upstate (W) | W | 66-68 |
| WNCAAB | 2022/02/12 19:00 | USC Upstate (W) v High Point (W) | L | 59-75 |
| WNCAAB | 2022/02/09 23:00 | Winthrop (W) v USC Upstate (W) | W | 47-59 |
| WNCAAB | 2022/03/01 19:00 | High Point (W) v Charleston Southern (W) | L | 54-34 |
| WNCAAB | 2022/02/26 19:00 | Charleston Southern (W) v UNC Asheville Women | L | 43-63 |
| WNCAAB | 2022/02/23 23:00 | North Carolina A&T (W) v Charleston Southern (W) | L | 76-42 |
| WNCAAB | 2022/02/19 19:00 | Charleston Southern (W) v High Point (W) | L | 50-71 |
| WNCAAB | 2022/02/17 22:30 | High Point (W) v Charleston Southern (W) | L | 69-60 |
| WNCAAB | 2022/02/15 23:00 | Winthrop (W) v Charleston Southern (W) | L | 56-43 |
| WNCAAB | 2022/02/12 19:00 | Charleston Southern (W) v Campbell (W) | L | 52-63 |
| WNCAAB | 2022/02/09 23:00 | Gardner Webb Women v Charleston Southern (W) | L | 90-51 |