Stadium: Colonial Life Arena
Home Manager: Clarisse Garcia Away Manager: Dawn Staley
| WNCAAB | 2022/03/01 19:00 | High Point (W) v Charleston Southern (W) | L | 54-34 |
| WNCAAB | 2022/02/26 19:00 | Charleston Southern (W) v UNC Asheville Women | L | 43-63 |
| WNCAAB | 2022/02/23 23:00 | North Carolina A&T (W) v Charleston Southern (W) | L | 76-42 |
| WNCAAB | 2022/02/19 19:00 | Charleston Southern (W) v High Point (W) | L | 50-71 |
| WNCAAB | 2022/02/17 22:30 | High Point (W) v Charleston Southern (W) | L | 69-60 |
| WNCAAB | 2022/02/15 23:00 | Winthrop (W) v Charleston Southern (W) | L | 56-43 |
| WNCAAB | 2022/02/12 19:00 | Charleston Southern (W) v Campbell (W) | L | 52-63 |
| WNCAAB | 2022/02/09 23:00 | Gardner Webb Women v Charleston Southern (W) | L | 90-51 |
| WNCAAB | 2022/04/04 00:00 | Connecticut (W) v South Carolina (W) | W | 49-64 |
| WNCAAB | 2022/04/01 23:00 | Louisville (W) v South Carolina (W) | W | 59-72 |
| WNCAAB | 2022/03/27 23:00 | Creighton (W) v South Carolina (W) | W | 50-80 |
| WNCAAB | 2022/03/25 23:00 | North Carolina (W) v South Carolina (W) | W | 61-69 |
| WNCAAB | 2022/03/20 19:00 | Miami Florida (W) v South Carolina (W) | W | 33-49 |
| WNCAAB | 2022/03/18 18:00 | Howard Women v South Carolina (W) | W | 21-79 |
| WNCAAB | 2022/03/06 19:00 | South Carolina (W) v Kentucky (W) | L | 62-64 |
| WNCAAB | 2022/03/05 22:00 | South Carolina (W) v Mississippi (W) | W | 61-51 |