Stadium: Edwin Fauver Stadium Round: 1
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | L | 34-10 |
| NCAAF | 2019/11/09 18:00 | St Lawrence Saints v Rochester Yellowjackets | L | 51-19 |
| NCAAF | 2018/10/06 17:00 | Rochester Yellowjackets v St Lawrence Saints | L | 24-38 |
| NCAAF | 2021/11/13 17:00 | Rochester Yellowjackets v Hobart Statesmen | L | 0-31 |
| NCAAF | 2021/11/06 17:00 | Hartwick Hawks v Rochester Yellowjackets | W | 28-42 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | L | 34-10 |
| NCAAF | 2021/10/23 16:00 | Rochester Yellowjackets v Union Dutchmen | L | 9-35 |
| NCAAF | 2021/10/16 20:00 | Buffalo State Bengals v Rochester Yellowjackets | W | 7-14 |
| NCAAF | 2021/10/09 16:00 | Rochester Yellowjackets v Ithaca Bombers | L | 14-37 |
| NCAAF | 2021/10/02 16:00 | Rpi Engineers v Rochester Yellowjackets | L | 38-22 |
| NCAAF | 2021/09/18 16:00 | Brockport Golden Eagles v Rochester Yellowjackets | L | 16-7 |
| NCAAF | 2021/11/13 17:00 | Buffalo State Bengals v St Lawrence Saints | W | 6-41 |
| NCAAF | 2021/11/06 17:00 | St Lawrence Saints v Rpi Engineers | L | 20-22 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | W | 34-10 |
| NCAAF | 2021/10/23 17:00 | Hobart Statesmen v St Lawrence Saints | L | 17-13 |
| NCAAF | 2021/10/16 17:00 | St Lawrence Saints v Ithaca Bombers | L | 0-17 |
| NCAAF | 2021/10/09 17:00 | Union Dutchmen v St Lawrence Saints | L | 37-7 |
| NCAAF | 2021/09/25 20:00 | St Lawrence Saints v Castleton Spartans | W | 55-3 |
| NCAAF | 2021/09/17 23:00 | Morrisville State Mustangs v St Lawrence Saints | W | 14-27 |