Stadium: Blackstock Stadium Round: 1
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | W | 30-34 |
| NCAAF | 2019/10/05 17:00 | Depauw Tigers v Wooster Scots | W | 31-26 |
| NCAAF | 2018/09/22 17:00 | Wooster Scots v Depauw Tigers | L | 24-21 |
| NCAAF | 2021/11/27 18:00 | UW-Whitewater v Depauw Tigers | L | 45-0 |
| NCAAF | 2021/11/20 17:00 | Depauw Tigers v Rose Hulman Engineers | W | 26-21 |
| NCAAF | 2021/11/13 18:07 | Wabash Little Giants v Depauw Tigers | L | 42-35 |
| NCAAF | 2021/11/06 17:00 | Depauw Tigers v Oberlin Yeomen | W | 66-13 |
| NCAAF | 2021/10/30 17:00 | Depauw Tigers v Denison Big Red | W | 27-10 |
| NCAAF | 2021/10/23 17:00 | Allegheny Gators v Depauw Tigers | W | 14-38 |
| NCAAF | 2021/10/16 17:00 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 24-7 |
| NCAAF | 2021/10/09 18:00 | Wittenberg Tigers v Depauw Tigers | W | 14-17 |
| NCAAF | 2021/11/13 18:00 | Wittenberg Tigers v Wooster Scots | L | 44-29 |
| NCAAF | 2021/11/06 17:00 | Wooster Scots v Allegheny Gators | W | 59-41 |
| NCAAF | 2021/10/30 16:00 | Wooster Scots v Hiram Terriers | W | 51-14 |
| NCAAF | 2021/10/23 19:00 | Denison Big Red v Wooster Scots | L | 52-28 |
| NCAAF | 2021/10/16 17:00 | Wabash Little Giants v Wooster Scots | W | 41-44 |
| NCAAF | 2021/10/02 17:00 | Oberlin Yeomen v Wooster Scots | W | 24-28 |
| NCAAF | 2021/09/25 18:00 | Wooster Scots v Depauw Tigers | L | 30-34 |
| NCAAF | 2021/09/18 17:00 | Ohio Wesleyan Battling Bishops v Wooster Scots | L | 31-7 |