[9] Harlequins 5-35 London Irish [12] 2017-12-02 18:00
Stadium: London Round: 19
Referee: Ian Tempest Home Manager: Mark Mapletoft Away Manager: Nick Kennedy
Head to Head
| Prem Rugby | 2017/09/02 15:45 | London Irish v Harlequins | L | 39-29 |
| Prem Rugby | 2016/05/01 14:00 | London Irish v Harlequins | W | 25-32 |
| European Rugby Challenge Cup | 2016/04/09 19:05 | Harlequins v London Irish | W | 38-30 |
| Prem Rugby | 2015/12/05 15:00 | Harlequins v London Irish | W | 38-7 |
| Prem Rugby | 2015/03/07 15:00 | Harlequins v London Irish | W | 26-20 |
| Prem Rugby | 2014/09/06 15:30 | London Irish v Harlequins | W | 15-20 |
Home History
| Prem Rugby | 2017/11/25 12:45 | Bath v Harlequins | L | 38-14 |
| Prem Rugby | 2017/11/19 15:00 | Exeter Chiefs v Harlequins | L | 31-17 |
| LV Cup | 2017/11/12 15:00 | Harlequins v Worcester Warriors | W | 45-37 |
| LV Cup | 2017/11/05 15:00 | Saracens v Harlequins | W | 29-30 |
| Premiership Rugby Shield | 2017/10/29 14:15 | Harlequins v Saracens Storm | W | 40-26 |
| Prem Rugby | 2017/10/28 14:00 | Harlequins v Worcester Warriors | W | 41-35 |
| Premiership Rugby Shield | 2017/10/23 18:30 | Gloucester United v Harlequins | W | 26-36 |
| European Rugby Champions Cup | 2017/10/22 16:30 | Wasps v Harlequins | L | 41-10 |
Away History
| Prem Rugby | 2017/12/02 15:00 | Gloucester v London Irish | L | 39-15 |
| Prem Rugby | 2017/11/26 15:00 | London Irish v Wasps | L | 13-17 |
| Prem Rugby | 2017/11/19 15:00 | London Irish v Bath | L | 18-22 |
| LV Cup | 2017/11/11 12:30 | Gloucester v London Irish | L | 47-7 |
| LV Cup | 2017/11/04 15:00 | London Irish v Bath | L | 22-26 |
| Prem Rugby | 2017/10/28 14:00 | Saracens v London Irish | L | 44-13 |
| European Rugby Challenge Cup | 2017/10/21 18:45 | Stade Francais v London Irish | W | 7-44 |
| European Rugby Challenge Cup | 2017/10/14 14:00 | London Irish v Edinburgh | L | 14-37 |