Stadium: Target Center Round: 140
Home Manager: Jeff Walz Away Manager: Dawn Staley
| WNCAAB | 2022/02/20 19:00 | Virginia Tech (W) v Louisville (W) | W | 56-70 |
| WNCAAB | 2022/02/17 23:00 | Louisville (W) v North Carolina (W) | L | 65-66 |
| WNCAAB | 2022/02/13 19:00 | Notre Dame (W) v Louisville (W) | W | 47-73 |
| WNCAAB | 2022/02/06 17:00 | Louisville (W) v Syracuse (W) | W | 100-64 |
| WNCAAB | 2022/02/03 23:00 | Louisville (W) v Clemson (W) | W | 93-71 |
| WNCAAB | 2022/02/02 00:00 | Louisville (W) v Miami Florida (W) | W | 69-66 |
| WNCAAB | 2022/01/30 20:00 | Duke (W) v Louisville (W) | W | 65-77 |
| WNCAAB | 2022/01/28 01:00 | Florida State (W) v Louisville (W) | W | 62-75 |
| WNCAAB | 2022/02/20 18:00 | Tennessee (W) v South Carolina (W) | W | 53-67 |
| WNCAAB | 2022/02/18 00:00 | Auburn (W) v South Carolina (W) | W | 38-75 |
| WNCAAB | 2022/02/13 17:00 | South Carolina (W) v Georgia (W) | W | 72-54 |
| WNCAAB | 2022/02/11 00:00 | South Carolina (W) v Kentucky (W) | W | 59-50 |
| WNCAAB | 2022/02/04 00:00 | Alabama (W) v South Carolina (W) | W | 51-83 |
| WNCAAB | 2022/01/30 17:00 | South Carolina (W) v Florida Women | W | 62-50 |
| WNCAAB | 2022/01/27 23:00 | Mississippi (W) v South Carolina (W) | W | 40-69 |
| WNCAAB | 2022/01/25 00:00 | Vanderbilt (W) v South Carolina (W) | W | 30-85 |