Stadium: Bon Secours Wellness Arena Round: 122
Home Manager: Bob McKillop Away Manager: Tom Izzo
| NCAAB | 2021/12/22 18:00 | Johnson & Wales (NC) v Davidson | W | 64-106 |
| NCAAB | 2021/12/22 00:00 | Davidson v Alabama | W | 79-78 |
| NCAAB | 2021/12/18 18:00 | Radford v Davidson | W | 54-74 |
| NCAAB | 2021/12/12 19:00 | Davidson v Northeastern | W | 79-69 |
| NCAAB | 2021/12/04 20:00 | William & Mary v Davidson | W | 46-70 |
| NCAAB | 2021/12/01 00:00 | Davidson v Charlotte U | W | 75-58 |
| NCAAB | 2021/11/27 19:00 | Robert Morris v Davidson | W | 70-88 |
| NCAAB | 2021/11/21 23:00 | Davidson v East Carolina | W | 76-67 |
| NCAAB | 2021/12/22 00:30 | Michigan State v Oakland | W | 90-78 |
| NCAAB | 2021/12/11 19:00 | Penn State v Michigan State | W | 64-80 |
| NCAAB | 2021/12/09 02:00 | Michigan State v Minnesota | W | 75-67 |
| NCAAB | 2021/12/04 22:00 | Toledo v Michigan State | W | 68-81 |
| NCAAB | 2021/12/02 00:15 | Louisville v Michigan State | W | 64-73 |
| NCAAB | 2021/11/26 16:00 | Baylor Bears v Michigan State | L | 75-58 |
| NCAAB | 2021/11/25 17:00 | Connecticut v Michigan State | W | 60-64 |
| NCAAB | 2021/11/24 15:00 | Loyola Chicago v Michigan State | W | 61-63 |