[6] BUF Sabres 1-6 EDM Oilers [3] 2022-01-20 19:00
Stadium: Rogers Place
Home Manager: Don Granato Away Manager: Jay Woodcroft
Head to Head
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2020/01/03 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2019/12/09 01:00 | BUF Sabres v EDM Oilers | W | 3-2 |
| NHL | 2019/03/05 00:00 | EDM Oilers v BUF Sabres | L | 4-3 |
| NHL | 2019/01/15 02:00 | BUF Sabres v EDM Oilers | L | 2-7 |
| NHL | 2018/01/24 02:00 | BUF Sabres v EDM Oilers | W | 5-0 |
| NHL | 2017/11/25 00:00 | EDM Oilers v BUF Sabres | W | 1-3 |
| NHL | 2016/12/07 00:00 | EDM Oilers v BUF Sabres | W | 3-4 |
Home History
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | L | 3-2 |
| NHL | 2022/01/16 00:00 | BUF Sabres v DET Red Wings | L | 0-4 |
| NHL | 2022/01/14 01:00 | BUF Sabres v NSH Predators | W | 4-1 |
| NHL | 2022/01/12 00:00 | TB Lightning v BUF Sabres | L | 6-1 |
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | L | 3-2 |
| NHL | 2022/01/01 18:00 | BUF Sabres v BOS Bruins | L | 3-4 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
Away History
| NHL | 2022/01/16 03:00 | OTT Senators v EDM Oilers | L | 6-4 |
| NHL | 2022/01/06 00:00 | EDM Oilers v TOR Maple Leafs | L | 2-4 |
| NHL | 2022/01/04 00:00 | EDM Oilers v NY Rangers | L | 1-4 |
| NHL | 2022/01/01 19:00 | EDM Oilers v NY Islanders | L | 2-3 |
| NHL | 2021/12/31 18:00 | EDM Oilers v NJ Devils | L | 5-6 |
| NHL | 2021/12/30 01:30 | EDM Oilers v STL Blues | L | 2-4 |
| NHL | 2021/12/19 03:00 | EDM Oilers v SEA Kraken | W | 5-3 |
| NHL | 2021/12/17 02:00 | CLB Blue Jackets v EDM Oilers | W | 2-5 |