Stadium: Alumni Coliseum McBrayer Arena
Home Manager: Carey Green Away Manager: Greg Todd
| WNCAAB | 2021/11/14 00:00 | Ohio (W) v Liberty (W) | W | 63-66 |
| WNCAAB | 2021/11/10 00:00 | Liberty (W) v Belmont Abbey Women | W | 89-40 |
| WNCAAB | 2021/03/14 18:00 | Liberty (W) v Florida Gulf Coast (W) | L | 62-84 |
| WNCAAB | 2021/03/13 00:00 | North Florida (W) v Liberty (W) | W | 52-65 |
| WNCAAB | 2021/03/12 00:00 | Bellarmine (W) v Liberty (W) | W | 59-88 |
| WNCAAB | 2021/03/06 22:00 | Florida Gulf Coast (W) v Liberty (W) | L | 65-50 |
| WNCAAB | 2021/03/06 00:00 | Florida Gulf Coast (W) v Liberty (W) | L | 80-60 |
| WNCAAB | 2021/02/28 19:00 | Stetson Women v Liberty (W) | W | 55-66 |
| WNCAAB | 2021/11/18 00:00 | Eastern Kentucky (W) v Evansville (W) | L | 57-67 |
| WNCAAB | 2021/11/14 19:00 | Eastern Kentucky (W) v Northern Kentucky Women | L | 61-76 |
| WNCAAB | 2021/11/11 23:00 | Eastern Kentucky (W) v Transylvania Women | W | 74-51 |
| WNCAAB | 2021/02/27 21:00 | Tennessee State (W) v Eastern Kentucky (W) | W | 64-69 |
| WNCAAB | 2021/02/25 22:00 | Belmont (W) v Eastern Kentucky (W) | L | 79-55 |
| WNCAAB | 2021/02/22 22:30 | Eastern Kentucky (W) v Austin Peay Women | L | 49-65 |
| WNCAAB | 2021/02/20 19:00 | Tennessee Martin (W) v Eastern Kentucky (W) | L | 81-62 |
| WNCAAB | 2021/02/19 00:00 | SE Missouri State (W) v Eastern Kentucky (W) | W | 72-82 |