Stadium: State Farm Center
Home Manager: Samantha Quigley Smith Away Manager: Nancy Fahey
| WNCAAB | 2021/02/27 19:00 | SIU Edwardsville (W) v SE Missouri State (W) | L | 52-63 |
| WNCAAB | 2021/02/25 19:00 | Tennessee Martin (W) v SIU Edwardsville (W) | L | 68-52 |
| WNCAAB | 2021/02/22 19:00 | Jacksonville State Women v SIU Edwardsville (W) | L | 61-47 |
| WNCAAB | 2021/02/20 22:30 | Murray State (W) v SIU Edwardsville (W) | L | 68-60 |
| WNCAAB | 2021/02/18 22:30 | SIU Edwardsville (W) v Austin Peay (W) | L | 40-66 |
| WNCAAB | 2021/02/13 19:00 | Jacksonville State Women v SIU Edwardsville (W) | L | 86-42 |
| WNCAAB | 2021/02/11 23:00 | Tennessee Tech (W) v SIU Edwardsville (W) | L | 81-42 |
| WNCAAB | 2021/02/06 22:00 | SIU Edwardsville (W) v Belmont (W) | L | 33-78 |
| WNCAAB | 2021/03/10 18:00 | Illinois (W) v Northwestern (W) | L | 42-67 |
| WNCAAB | 2021/03/09 22:00 | Wisconsin (W) v Illinois (W) | W | 42-67 |
| WNCAAB | 2021/03/05 22:00 | Minnesota (W) v Illinois (W) | W | 64-72 |
| WNCAAB | 2021/02/28 19:00 | Illinois (W) v Purdue (W) | L | 66-70 |
| WNCAAB | 2021/02/25 00:00 | Illinois (W) v Northwestern (W) | L | 61-67 |
| WNCAAB | 2021/02/20 17:00 | Illinois (W) v Rutgers (W) | L | 46-75 |
| WNCAAB | 2021/02/17 18:00 | Illinois (W) v Maryland (W) | L | 58-103 |
| WNCAAB | 2021/02/14 20:00 | Indiana (W) v Illinois (W) | L | 58-50 |