Stadium: Purcell Pavilion
Home Manager: Maria Marchesano Away Manager: Niele Ivey
| WNCAAB | 2021/02/25 22:00 | Purdue Fort Wayne Women v Youngstown State Women | L | 59-62 |
| WNCAAB | 2021/02/20 17:00 | Robert Morris (W) v Purdue Fort Wayne Women | L | 77-63 |
| WNCAAB | 2021/02/19 19:00 | Robert Morris (W) v Purdue Fort Wayne Women | W | 67-71 |
| WNCAAB | 2021/02/13 18:00 | Cleveland State Women v Purdue Fort Wayne Women | L | 71-61 |
| WNCAAB | 2021/02/12 18:00 | Purdue Fort Wayne Women v Cleveland State Women | L | 45-68 |
| WNCAAB | 2021/02/06 18:00 | Youngstown State Women v Purdue Fort Wayne Women | L | 68-52 |
| WNCAAB | 2021/02/05 19:00 | Purdue Fort Wayne Women v Youngstown State Women | L | 60-102 |
| WNCAAB | 2021/01/30 19:00 | Purdue Fort Wayne Women v Wright State (W) | L | 59-69 |
| WNCAAB | 2021/03/05 01:30 | Clemson Women v Notre Dame (W) | L | 68-63 |
| WNCAAB | 2021/02/28 20:00 | Louisville (W) v Notre Dame (W) | L | 78-61 |
| WNCAAB | 2021/02/26 00:00 | Florida State (W) v Notre Dame (W) | W | 64-72 |
| WNCAAB | 2021/02/23 01:00 | Notre Dame (W) v Pittsburgh (W) | W | 59-48 |
| WNCAAB | 2021/02/07 19:00 | Notre Dame (W) v Louisville (W) | L | 65-71 |
| WNCAAB | 2021/01/31 16:00 | Notre Dame (W) v Syracuse (W) | L | 69-81 |
| WNCAAB | 2021/01/24 17:00 | Notre Dame (W) v North Carolina (W) | L | 73-78 |
| WNCAAB | 2021/01/22 00:00 | Virginia Tech Women v Notre Dame (W) | W | 60-65 |