Stadium: Foster Auditorium
Home Manager: Clarisse Garcia Away Manager: Kristy Curry
| WNCAAB | 2021/03/06 19:00 | USC Upstate (W) v Charleston Southern (W) | L | 72-64 |
| WNCAAB | 2021/02/21 18:00 | Charleston Southern (W) v Radford (W) | L | 67-76 |
| WNCAAB | 2021/02/20 19:00 | Radford (W) v Charleston Southern (W) | L | 74-73 |
| WNCAAB | 2021/02/13 20:00 | Longwood (W) v Charleston Southern (W) | L | 76-51 |
| WNCAAB | 2021/02/13 00:00 | Longwood (W) v Charleston Southern (W) | L | 94-48 |
| WNCAAB | 2021/02/06 23:00 | Charleston Southern (W) v High Point (W) | L | 54-71 |
| WNCAAB | 2021/02/06 00:00 | Charleston Southern (W) v High Point (W) | L | 65-88 |
| WNCAAB | 2021/01/30 18:00 | Winthrop (W) v Charleston Southern (W) | L | 53-48 |
| WNCAAB | 2021/03/24 17:00 | Alabama (W) v Maryland (W) | L | 64-100 |
| WNCAAB | 2021/03/22 16:00 | North Carolina (W) v Alabama (W) | W | 71-80 |
| WNCAAB | 2021/03/05 23:00 | Alabama (W) v South Carolina (W) | L | 63-75 |
| WNCAAB | 2021/03/04 23:00 | Missouri (W) v Alabama (W) | W | 74-82 |
| WNCAAB | 2021/02/28 23:00 | Alabama (W) v Arkansas (W) | L | 76-94 |
| WNCAAB | 2021/02/26 00:00 | Alabama (W) v Texas A&M (W) | L | 67-73 |
| WNCAAB | 2021/02/21 20:00 | Mississippi State (W) v Alabama (W) | W | 63-71 |
| WNCAAB | 2021/02/18 22:00 | Alabama (W) v Florida Women | W | 77-70 |