[6] Michigan State 29-40 Purdue [51] 2021-07-17 07:30
Stadium: Ross-Ade Stadium Round: 1
Home Manager: Melvin Tucker Away Manager: Jeff Brohm
Head to Head
| NCAAF | 2018/10/27 16:00 | Purdue v Michigan State | W | 13-23 |
| NCAAF | 2015/10/03 16:00 | Michigan State v Purdue | W | 24-21 |
| NCAAF | 2014/10/11 19:30 | Purdue v Michigan State | W | 31-45 |
| NCAAF | 2010/11/20 12:00 | Michigan State v Purdue | W | 35-31 |
| NCAAF | 2009/11/14 12:00 | Purdue v Michigan State | W | 37-40 |
| NCAAF | 2008/11/08 12:00 | Michigan State v Purdue | W | 21-7 |
| NCAAF | 2007/11/10 12:00 | Purdue v Michigan State | W | 31-48 |
| NCAAF | 2006/11/04 12:00 | Michigan State v Purdue | L | 15-17 |
Home History
| NCAAF | 2020/12/12 17:00 | Michigan State v Penn State | L | 24-39 |
| NCAAF | 2020/12/05 17:00 | Ohio State v Michigan State | L | 52-12 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | W | 20-29 |
| NCAAF | 2020/11/14 17:00 | Indiana v Michigan State | L | 24-0 |
| NCAAF | 2020/11/07 17:00 | Michigan State v Iowa | L | 7-49 |
| NCAAF | 2020/10/31 16:00 | Michigan State v Michigan | W | 27-24 |
| NCAAF | 2020/10/24 16:00 | Rutgers v Michigan State | L | 38-27 |
| NCAAF | 2019/12/27 20:20 | Michigan State v Wake Forest | W | 27-21 |
Away History
| NCAAF | 2020/12/05 17:00 | Nebraska v Purdue | L | 37-27 |
| NCAAF | 2020/11/28 21:00 | Rutgers v Purdue | L | 37-30 |
| NCAAF | 2020/11/21 00:30 | Purdue v Minnesota | L | 31-34 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | L | 27-20 |
| NCAAF | 2020/10/31 16:00 | Purdue v Illinois | W | 31-24 |
| NCAAF | 2020/10/24 19:30 | Iowa v Purdue | W | 20-24 |
| NCAAF | 2019/11/30 17:00 | Indiana v Purdue | L | 44-41 |
| NCAAF | 2019/11/23 21:00 | Purdue v Wisconsin | L | 24-45 |