[7] Hamrun Spartans 3-0 St Lucia [10] 2021-10-15 11:00
Stadium: Victor Tedesco Stadium Round: 10
Home Manager: Mark Buttigieg Away Manager: Oliver Spiteri
Head to Head
| Europe Friendlies | 2021/07/16 18:00 | Hamrun Spartans v Santa Lucia FC | D | 0-0 |
| Malta Premier League | 2021/01/24 17:00 | Hamrun Spartans v Santa Lucia FC | D | 2-2 |
| Malta Premier League | 2020/09/27 15:00 | Santa Lucia FC v Hamrun Spartans | W | 1-4 |
| Malta Premier League | 2019/11/01 19:15 | Hamrun Spartans v Santa Lucia FC | D | 1-1 |
Home History
| Malta Premier League | 2021/09/25 17:00 | Floriana v Hamrun Spartans | W | 1-2 |
| Malta Premier League | 2021/09/19 19:00 | Hamrun Spartans v Balzan FC | L | 0-1 |
| Malta Premier League | 2021/09/11 15:00 | Mosta FC v Hamrun Spartans | W | 1-2 |
| Malta Premier League | 2021/08/21 17:00 | Birkirkara v Hamrun Spartans | L | 2-1 |
| Malta Premier League | 2021/08/13 18:00 | Hamrun Spartans v Valletta | L | 1-2 |
| Europe Friendlies | 2021/07/16 18:00 | Hamrun Spartans v Santa Lucia FC | D | 0-0 |
| Europe Friendlies | 2021/06/30 18:00 | Gzira United v Hamrun Spartans | L | 2-1 |
| Malta Premier League | 2021/03/06 13:00 | Hamrun Spartans v Hibernians | W | 1-0 |
Away History
| Malta Premier League | 2021/09/25 19:00 | Hibernians v Santa Lucia FC | D | 1-1 |
| Malta Premier League | 2021/09/18 15:00 | Santa Lucia FC v Sirens | L | 1-3 |
| Malta Premier League | 2021/09/12 19:00 | Gudja United v Santa Lucia FC | D | 2-2 |
| Malta Premier League | 2021/08/22 17:00 | Santa Lucia FC v Gzira United | D | 1-1 |
| Malta Premier League | 2021/08/14 18:00 | Floriana v Santa Lucia FC | D | 2-2 |
| Europe Friendlies | 2021/07/16 18:00 | Hamrun Spartans v Santa Lucia FC | D | 0-0 |
| Malta Premier League | 2021/03/06 17:00 | Lija Athletic v Santa Lucia FC | L | 3-1 |
| Malta FA Trophy | 2021/03/03 17:30 | Santa Lucia FC v Mosta FC | L | 0-2 |