[7] TEN Titans 34-31 IND Colts [21] 2021-10-21 17:00
Stadium: Lucas Oil Stadium Round: 1
Head to Head
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | W | 16-25 |
| NFL | 2020/11/29 18:00 | TEN Titans v IND Colts | W | 45-26 |
| NFL | 2020/11/13 01:20 | IND Colts v TEN Titans | L | 34-17 |
| NFL | 2019/12/01 18:00 | TEN Titans v IND Colts | W | 31-17 |
| NFL | 2019/09/15 17:00 | IND Colts v TEN Titans | L | 19-17 |
| NFL | 2018/12/31 01:20 | IND Colts v TEN Titans | L | 33-17 |
| NFL | 2018/11/18 18:00 | TEN Titans v IND Colts | L | 10-38 |
| NFL | 2017/11/26 18:00 | TEN Titans v IND Colts | W | 20-16 |
Home History
| NFL | 2021/10/19 00:15 | BUF Bills v TEN Titans | W | 31-34 |
| NFL | 2021/10/10 17:00 | TEN Titans v JAX Jaguars | W | 37-19 |
| NFL | 2021/10/03 17:00 | TEN Titans v NY Jets | L | 24-27 |
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | W | 16-25 |
| NFL | 2021/09/19 20:25 | TEN Titans v SEA Seahawks | W | 33-30 |
| NFL | 2021/09/12 17:00 | ARZ Cardinals v TEN Titans | L | 38-13 |
| NFL Preseason | 2021/08/28 23:00 | CHI Bears v TEN Titans | L | 27-24 |
| NFL Preseason | 2021/08/21 23:30 | TEN Titans v TB Buccaneers | W | 34-3 |
Away History
| NFL | 2021/10/17 17:00 | HOU Texans v IND Colts | W | 3-31 |
| NFL | 2021/10/12 00:15 | IND Colts v BAL Ravens | L | 25-31 |
| NFL | 2021/10/03 17:00 | IND Colts v MIA Dolphins | W | 27-17 |
| NFL | 2021/09/26 17:00 | IND Colts v TEN Titans | L | 16-25 |
| NFL | 2021/09/19 17:00 | LA Rams v IND Colts | L | 27-24 |
| NFL | 2021/09/12 17:00 | SEA Seahawks v IND Colts | L | 28-16 |
| NFL Preseason | 2021/08/27 23:00 | IND Colts v DET Lions | W | 27-17 |
| NFL Preseason | 2021/08/22 00:00 | IND Colts v MIN Vikings | W | 12-10 |