Home History
| NCAAF | 2000/10/28 12:00 | USC v California | L | 16-28 |
| NCAAF | 2000/10/21 12:00 | Stanford v USC | L | 32-30 |
| NCAAF | 2000/10/14 12:00 | USC v Oregon | L | 17-28 |
| NCAAF | 2000/10/07 12:00 | USC v Arizona | L | 15-31 |
| NCAAF | 2000/09/30 12:00 | Oregon State v USC | L | 31-21 |
| NCAAF | 2000/09/23 12:00 | USC v San Jose State | W | 34-24 |
| NCAAF | 2000/09/09 12:00 | USC v Colorado | W | 17-14 |
| NCAAF | 2000/08/27 12:00 | Penn State v USC | W | 5-29 |
Away History
| NCAAF | 2000/10/28 12:00 | Notre Dame v Air Force | W | 34-31 |
| NCAAF | 2000/10/21 12:00 | West Virginia v Notre Dame | W | 28-42 |
| NCAAF | 2000/10/14 12:00 | Navy v Notre Dame | W | 14-45 |
| NCAAF | 2000/10/07 12:00 | Notre Dame v Stanford | W | 20-14 |
| NCAAF | 2000/09/23 12:00 | Michigan State v Notre Dame | L | 27-21 |
| NCAAF | 2000/09/16 12:00 | Notre Dame v Purdue | W | 23-21 |
| NCAAF | 2000/09/09 12:00 | Notre Dame v Nebraska | L | 24-27 |
| NCAAF | 2000/09/02 12:00 | Notre Dame v Texas A&M | W | 24-10 |