Stadium: NRG Stadium Round: 8
Home Manager: Kyle Shanahan Away Manager: DeMeco Ryans
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 0 | 7 | 7 | 8 | 0 | 15 |
| 3 | 13 | 16 | 7 | 3 | 26 |
| SF 49ers | HOU Texans |
| Lineup | |
|---|---|
| 17 - WR - Jordan Watkins | Tommy Togiai - DT - 72 |
| 62 - OL - Austen Pleasants | E.J. Speed - Left back - 45 |
| 92 - DT - Jordan Elliott | Derek Stingley Jr. - Center back - 24 |
| 68 - OL - Colton McKivitz | Christian Harris - Left back - 48 |
| 61 - OL - Matt Hennessy | Jared Wayne - WR - 89 |
| 95 - DT - Alfred Collins | Calen Bullock - SAF - 2 |
| 20 - DB - Upton Stout | British Brooks - Right back - 44 |
| 98 - DE - Mykel Williams | Jake Andrews - Center - 60 |
| 65 - OL - Drew Moss | Dylan Horton - DE - 92 |
| 2 - DB - Deommodore Lenoir | Juice Scruggs - OL - 70 |
| 25 - Center back - Jason Pinnock | Dameon Pierce - Right back - 31 |
| 44 - FB - Kyle Juszczyk | Nick Chubb - Right back - 21 |
| 7 - K - Thomas Morstead | Jarrett Patterson - OL - 54 |
| 71 - OL - Trent Williams | Jalen Pitre - SAF - 5 |
| 46 - LS - Jon Weeks | Henry To'o To'o - Left back - 39 |
| 3 - Right back - Brian Robinson | Jamal Hill - Left back - 56 |
| 45 - Left back - Nickolas Martin | Xavier Hutchinson - WR - 19 |
| 77 - OL - Dominick Puni | Jayden Higgins - WR - 81 |
| 75 - OL - Connor Colby | Blake Fisher - OL - 57 |
| 56 - Left back - Trevis Gipson | Kamari Lassiter - DB - 4 |
| 36 - SAF - Marques Sigle | Jaylin Smith - Center back - 22 |
| 5 - WR - Demarcus Robinson | Jaylin Noel - WR - 14 |
| 23 - Right back - Christian McCaffrey | Jaylen Reed - SAF - 23 |
| 90 - DT - Kevin Givens | Austin Brinkman - - 40 |
| 89 - TE - Luke Farrell | Harrison Bryant - TE - 88 |
| 31 - Right back - Isaac Guerendo | Tommy Townsend - Pivot - 6 |
| 18 - K - Eddy Pineiro | Jo'Quavious Marks - Right back - 27 |
| 51 - Left back - Robert Beal Jr. | Will Anderson Jr. - Left back - 51 |
| 63 - OL - Nick Zakelj | C.J. Stroud - QB - 7 |
| 15 - WR - Jauan Jennings | Aireontae Ersery - OL - 79 |
| 10 - QB - Mac Jones | Ed Ingram - OL - 69 |
| 26 - DB - Chase Lucas | Jake Hansen - Left back - 35 |
| 93 - DL - Kalia Davis | Danielle Hunter - DE - 55 |
| - DB - Renardo Green | Braxton Berrios - WR - 17 |
| 59 - OLB - Curtis Robinson | Laken Tomlinson - OG - 75 |
| 28 - Center back - Darrell Luter Jr. | Mario Edwards Jr. - DE - 97 |
| 6 - DB - Malik Mustapha | Dare Ogunbowale - Right back - 33 |
| 88 - TE - Jake Tonges | Tremon Smith - Center back - 11 |
| 27 - SAF - Ji'Ayir Brown | Derek Barnett - DE - 95 |
| 85 - TE - George Kittle | Tytus Howard - OL - 71 |
| 84 - WR - Kendrick Bourne | Denico Autry - DL - 96 |
| 9 - WR - Skyy Moore | Dalton Schultz - TE - 86 |
| 91 - DT - Sam Okuayinonu | M.J. Stewart - Center back - 29 |
| 48 - Left back - Tatum Bethune | Sheldon Rankins - DE - 90 |
| 33 - Center back - Siran Neal | Tim Settle - DT - 98 |
| 53 - Left back - Dee Winters | Ka'imi Fairbairn - K - 15 |
| 57 - Left back - Luke Gifford | Azeez Al-Shaair - Left back - |
| Substitutes | |