| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 14 | 7 | 21 | 14 | 13 | 48 |
| 0 | 14 | 14 | 7 | 21 | 42 |
| BUF Bills | DET Lions |
| Lineup | |
|---|---|
| 57 - DE - A.J. Epenesa | Brock Wright - TE - 89 |
| 85 - TE - Quintin Morris | Jameson Williams - WR - 1 |
| 29 - DB - Brandon Codrington | Brandon Joseph - FS - 12 |
| 69 - LS - Reid Ferguson | Sam LaPorta - TE - 87 |
| 90 - DT - DeWayne Carter | Jack Campbell - Left back - 46 |
| 5 - Center back - Kaiir Elam | Al-Quadin Muhammad - DL - 96 |
| 76 - OL - David Edwards | Taylor Decker - OT - 68 |
| 2 - K - Tyler Bass | Penei Sewell - OL - 58 |
| 79 - OT - Spencer Brown | Kerby Joseph - DB - 31 |
| 26 - Right back - Ty Johnson | Josh Paschal - DE - 93 |
| 92 - DT - Daquan Jones | Carlton Davis - DB - 23 |
| 24 - SAF - Cole Bishop | Ben Niemann - Left back - 51 |
| - WR - Keon Coleman | David Montgomery - Right back - 5 |
| 8 - Pivot - Sam Martin | Ezekiel Turner - DB - 47 |
| 18 - WR - Amari Cooper | Sione Vaki - Right back - 33 |
| 40 - Left back - Von Miller | Craig Reynolds - Right back - 13 |
| 62 - OL - Sedrick Van Pran-Granger | Christian Mahogany - OL - 73 |
| 52 - DT - Jordan Phillips | Shane Zylstra - TE - 84 |
| 27 - DB - Kareem Jackson | Levi Onwuzurike - DT - 91 |
| 50 - DE - Gregory Rousseau | Alim McNeill - DT - 54 |
| 66 - OL - Connor McGovern | Amon-Ra St. Brown - WR - 14 |
| 70 - OT - Alec Anderson | Terrion Arnold - DB - 6 |
| 4 - Right back - James Cook | Jake Bates - K - 39 |
| 7 - Center back - Taron Johnson | Jahmyr Gibbs - Right back - 26 |
| 8 - Left back - Terrel Bernard | Jonah Williams - DE - 78 |
| 74 - OL - Ryan Van Demark | Kindle Vildor - Center back - 29 |
| 46 - SAF - Ja'Marcus Ingram | Amik Robertson - Center back - 21 |
| 54 - Left back - Baylon Spector | Brian Branch - DB - 32 |
| 88 - TE - Dawson Knox | Abraham Beauplan - Left back - 48 |
| 39 - Center back - Cam Lewis | Hogan Hatten - Left back - 49 |
| 91 - DT - Ed Oliver | Maurice Alexander - WR - 1 |
| 17 - QB - Josh Allen | David Long - Left back - 43 |
| 10 - WR - Khalil Shakir | Frank Ragnow - OL - 77 |
| 98 - DT - Austin Johnson | Dan Skipper - OL - 70 |
| 44 - Left back - Joe Andreessen | Pat O'Connor - DL - 95 |
| 73 - OL - Dion Dawkins | Za'Darius Smith - DE - 99 |
| 64 - Guard - O'Cyrus Torrence | Kwon Alexander - Left back - 10 |
| 56 - Left back - Javon Solomon | Graham Glasgow - Center - 60 |
| 42 - Left back - Dorian Williams | Jared Goff - QB - 16 |
| 22 - Right back - Ray Davis | Tim Patrick - WR - 17 |
| 94 - DL - Dawuane Smoot | D.J. Reader - DT - 98 |
| 1 - Right back - Curtis Samuel | Michael Niese - OL - 62 |
| 13 - WR - Mack Hollins | Jamal Adams - SAF - 25 |
| 58 - Left back - Matt Milano | Khalil Dorsey - SAF - 30 |
| 86 - TE - Dalton Kincaid | Allen Robinson - WR - 8 |
| 47 - DB - Christian Benford | Jack Fox - K - 3 |
| 41 - TE - Reggie Gilliam | Kevin Zeitler - OG - 71 |
| Substitutes | |