Stadium: NRG Stadium Round: 5
Home Manager: Sean McDermott Away Manager: DeMeco Ryans
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 3 | 0 | 3 | 14 | 3 | 20 |
| 14 | 3 | 17 | 3 | 3 | 23 |
| BUF Bills | HOU Texans |
| Lineup | |
|---|---|
| 69 - LS - Reid Ferguson | Rashad Weaver - OLB - 90 |
| 29 - DB - Brandon Codrington | Kenyon Green - OL - 76 |
| 11 - QB - Mitchell Trubisky | Nick Broeker - Guard - 64 |
| 5 - Center back - Kaiir Elam | Cade Stover - TE - 87 |
| 76 - OL - David Edwards | Derek Stingley Jr. - Center back - 24 |
| 57 - DE - A.J. Epenesa | John Metchie III - WR - 8 |
| 2 - K - Tyler Bass | Jarrett Patterson - OL - 54 |
| 85 - TE - Quintin Morris | British Brooks - Right back - 44 |
| 79 - OT - Spencer Brown | Dylan Horton - DE - 92 |
| 3 - SAF - Damar Hamlin | Juice Scruggs - OL - 70 |
| 8 - Pivot - Sam Martin | Kendrick Green - OL - 53 |
| 50 - DE - Gregory Rousseau | Jalen Pitre - SAF - 5 |
| 92 - DT - Daquan Jones | Del'Shawn Phillips - Left back - 13 |
| 24 - SAF - Cole Bishop | M.J. Stewart - Center back - 29 |
| 62 - OL - Sedrick Van Pran-Granger | D'Angelo Ross - DB - 37 |
| 99 - DE - Casey Toohill | Henry To'o To'o - Left back - 39 |
| - WR - Keon Coleman | Nico Collins - WR - 12 |
| 73 - OL - Dion Dawkins | Blake Fisher - OL - 57 |
| 66 - OL - Connor McGovern | Kamari Lassiter - DB - 4 |
| 64 - Guard - O'Cyrus Torrence | Calen Bullock - SAF - 2 |
| 39 - Center back - Cam Lewis | Tank Dell - WR - 3 |
| 53 - DL - Branson Deen | Myles Bryant - DB - 27 |
| 4 - Right back - James Cook | Cam Akers - Right back - 22 |
| 8 - Left back - Terrel Bernard | Tommy Townsend - Pivot - 6 |
| 74 - OL - Ryan Van Demark | Khalil Davis - DL - 94 |
| 46 - SAF - Ja'Marcus Ingram | Will Anderson Jr. - Left back - 51 |
| 54 - Left back - Baylon Spector | C.J. Stroud - QB - 7 |
| 80 - WR - Tyrell Shavers | Xavier Hutchinson - WR - 19 |
| 88 - TE - Dawson Knox | Jamal Hill - Left back - 56 |
| 26 - Right back - Ty Johnson | Kris Boyd - DB - 17 |
| 17 - QB - Josh Allen | J.J. Taylor - Right back - 26 |
| 15 - WR - Marquez Valdes-Scantling | Dalton Schultz - TE - 86 |
| 70 - OT - Alec Anderson | Jon Weeks - LS - 46 |
| 32 - Left back - Nicholas Morrow | Danielle Hunter - DE - 55 |
| 44 - Left back - Joe Andreessen | Laremy Tunsil - OL - 78 |
| 56 - Left back - Javon Solomon | Dare Ogunbowale - Right back - 33 |
| 42 - Left back - Dorian Williams | Neville Hewitt - Left back - 43 |
| 22 - Right back - Ray Davis | Mario Edwards Jr. - DE - 97 |
| 31 - Center back - Rasul Douglas | Stefon Diggs - WR - 1 |
| 94 - DL - Dawuane Smoot | Tim Settle - DT - 98 |
| 1 - Right back - Curtis Samuel | Eric Murray - Center back - 23 |
| 13 - WR - Mack Hollins | Ka'imi Fairbairn - K - 15 |
| 93 - DT - Zion Logue | Robert Woods - WR - 2 |
| 90 - DT - DeWayne Carter | Azeez Al-Shaair - Left back - |
| 86 - TE - Dalton Kincaid | Folorunso Fatukasi - DL - 91 |
| 47 - DB - Christian Benford | Jimmie Ward - SAF - 20 |
| 21 - SAF - Mike Edwards | Shaq Mason - OL - 69 |
| 41 - TE - Reggie Gilliam | - |
| Substitutes | |