Stadium: Highmark Stadium Round: 12
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 0 | 14 | 14 | 0 | 7 | 21 |
| 14 | 0 | 14 | 0 | 10 | 24 |
| JAX Jaguars | BUF Bills |
| Lineup | |
|---|---|
| 36 - SAF - Ronnie Harrison | Eddie Yarbrough - DE - 54 |
| 27 - Right back - Leonard Fournette | Isaiah McKenzie - WR - 19 |
| 48 - Left back - Leon Jacobs | Jason Croom - TE - 80 |
| 91 - DE - Yannick Ngakoue | Harrison Phillips - DT - 99 |
| 57 - MLB - Nick DeLuca | Chris Ivory - Right back - 33 |
| 90 - DE - Taven Bryan | Jeremiah Sirles - OT - 74 |
| 94 - DE - Dawuane Smoot | Kelvin Benjamin - WR - 13 |
| 53 - OLB - Blair Brown | Taron Johnson - Center back - 7 |
| 41 - Center back - Tre Herndon | Trent Murphy - DE - 93 |
| 84 - WR - Keelan Cole | Siran Neal - Center back - 29 |
| 54 - DT - Eli Ankou | Andre Holmes - WR - 18 |
| 9 - Pivot - Logan Cooke | Jordan Phillips - DE - 97 |
| 12 - WR - Dede Westbrook | Matt Milano - Left back - 58 |
| 26 - SAF - Jarrod Wilson | John Miller - OG - 76 |
| 44 - MLB - Myles Jack | Shaq Lawson - DE - 90 |
| 25 - Center back - DJ Hayden | Lafayette Pitts - Center back - 30 |
| 97 - DT - Malik Jackson | Deon Lacey - Left back - 44 |
| 93 - DE - Calais Campbell | Marcus Murphy - Right back - 45 |
| 34 - Right back - Carlos Hyde | Tre'Davious White - Center back - 27 |
| 40 - FB - Tommy Bohanon | Colton Schmidt - Pivot - 6 |
| 69 - OL - Tyler Shatley | Ryan Groy - Center - 72 |
| 21 - Center back - A.J. Bouye | Dion Dawkins - OT - 73 |
| 78 - OT - Jermey Parnell | Zay Jones - WR - 11 |
| 5 - QB - Blake Bortles | Reid Ferguson - LS - 69 |
| 22 - DB - Cody Davis | Deonte Thompson - WR - 10 |
| 10 - WR - Donte Moncrief | Julian Stanford - Left back - 51 |
| 50 - OLB - Telvin Smith | Jerry Hughes - DE - 55 |
| 95 - DT - Abry Jones | Lorenzo Alexander - OLB - 57 |
| 77 - OL - Patrick Omameh | Corey Thompson - Left back - 52 |
| 42 - SS - Barry Church | Kyle Williams - DT - 95 |
| 39 - FS - Tashaun Gipson | Jordan Poyer - SAF - 21 |
| 6 - QB - Cody Kessler | Russell Bodine - Center - 66 |
| 20 - Center back - Jalen Ramsey | Matt Barkley - QB - 5 |
| 64 - OG - Chris Reed | Rafael Bush - FS - 20 |
| 23 - Center back - Tyler Patmon | Jordan Mills - OT - 79 |
| 4 - K - Josh Lambo | Levi Wallace - Center back - 47 |
| 68 - OG - Andrew Norwell | Patrick DiMarco - FB - 42 |
| 80 - TE - James O'Shaughnessy | Steven Hauschka - K - 4 |
| 13 - WR - Rashad Greene | Star Lotulelei - DT - 98 |
| 87 - TE - Blake Bell | Micah Hyde - SAF - 23 |
| 83 - TE - Ben Koyack | Logan Thomas - TE - 82 |
| 47 - Left back - Martrell Spaight | Josh Allen - QB - 17 |
| 60 - OG - A.J. Cann | Tremaine Edmunds - Left back - 49 |
| 24 - Right back - T.J. Yeldon | LeSean McCoy - Right back - 25 |
| 75 - OT - Ereck Flowers | Robert Foster - WR - 16 |
| 45 - LS - Matt Overton | Wyatt Teller - OG - 75 |
| Substitutes | |