Stadium: Nissan Stadium Round: 1
Home Manager: Kyle Shanahan Away Manager: Mike Vrabel
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 3 | 10 | 0 | 7 | 17 |
| 0 | 0 | 0 | 10 | 10 | 20 |
| SF 49ers | TEN Titans |
| Lineup | |
|---|---|
| 1 - SAF - Jimmie Ward | Dillon Radunz - OT - 75 |
| 18 - Pivot - Mitch Wishnowsky | Khari Blasingame - Right back - 45 |
| 2 - DB - Deommodore Lenoir | Anthony Firkser - TE - 86 |
| 17 - WR - Travis Benjamin | Greg Mabin - DB - 30 |
| 15 - WR - Jauan Jennings | Kevin Strong - DT - 97 |
| 23 - Right back - JaMycal Hasty | Dylan Cole - Left back - 53 |
| 10 - QB - Jimmy Garoppolo | Corey Levin - OL - 62 |
| 92 - DL - Charles Omenihu | Jeremy McNichols - Right back - |
| 20 - Center back - Ambry Thomas | Jayon Brown - Left back - 55 |
| 11 - WR - Brandon Aiyuk | Zach Cunningham - MLB - 41 |
| 13 - WR - River Cracraft | D'Onta Foreman - Right back - 7 |
| 89 - TE - Charlie Woerner | Dontrell Hilliard - Right back - 40 |
| 65 - OG - Aaron Banks | Kyle Peko - DT - 95 |
| 66 - OL - Tom Compton | Chester Rogers - WR - 80 |
| 24 - DB - K'Waun Williams | Dane Cruikshank - Center back - 29 |
| 60 - TE - Daniel Brunskill | Jeffery Simmons - DT - 98 |
| 44 - FB - Kyle Juszczyk | Rashaan Evans - Left back - 54 |
| 30 - Right back - Jeffery Wilson | Racey McMath - WR - 81 |
| 90 - DT - Kevin Givens | Naquan Jones - DT - 90 |
| 97 - DL - Nick Bosa | Aaron Brewer - Center - 62 |
| 19 - WR - Deebo Samuel | Kristian Fulton - Center back - 26 |
| 95 - DE - Kentavius Street | Chris Jackson - DB - 35 |
| 91 - DL - Arik Armstead | Teair Tart - DL - 93 |
| 64 - OL - Jake Brendel | Nate Davis - OL - 64 |
| 75 - OG - Laken Tomlinson | A.J. Brown - WR - 11 |
| 56 - DL - Samson Ebukam | Amani Hooker - DB - 37 |
| 36 - Right back - Brian Hill | Christian DiLauro - OL - 69 |
| 3 - SAF - Jaquiski Tartt | Harold Landry III - DE - 58 |
| 85 - TE - George Kittle | Olasunkanmi Adeniyi - DE - 92 |
| 93 - DT - D.J. Jones | Nick Westbrook-Ikhine - WR - 15 |
| 27 - Center back - Dontae Johnson | Matthias Farley - Center back - 21 |
| 46 - LS - Taybor Pepper | Bud Dupree - OLB - 48 |
| 50 - Center - Alex Mack | Janoris Jenkins - Center back - 20 |
| 45 - SAF - Demetrius Flannigan-Fowles | Julio Jones - WR - 2 |
| 36 - DB - Marcell Harris | Morgan Cox - LS - 46 |
| 26 - Center back - Josh Norman | Ben Jones - K - 60 |
| 9 - K - Robbie Gould | Buster Skrine - Center back - 38 |
| 98 - Left back - Arden Key | David Quessenberry - OT - 72 |
| 71 - OL - Trent Williams | Randy Bullock - K - 14 |
| 82 - TE - Ross Dwelley | Ryan Tannehill - QB - 17 |
| 94 - DE - Jordan Willis | Denico Autry - DL - 96 |
| 51 - Left back - Azeez Al-Shaair | Nick Dzubnar - MLB - 49 |
| 81 - WR - Trent Sherfield | Geoff Swaim - TE - 87 |
| 54 - Left back - Fred Warner | Brett Kern - Pivot - 6 |
| 59 - OLB - Curtis Robinson | MyCole Pruitt - TE - 85 |
| - SAF - Jarrod Wilson | Kevin Byard - SAF - 31 |
| Substitutes | |