Stadium: Ernest Hawkins Field at Memorial Stadium Round: 1
Home Manager: Tim Rebowe Away Manager: Clint Dolezel
| NCAAF | 2022/11/18 00:00 | SE Louisiana v Nicholls State | L | 40-17 |
| NCAAF | 2022/11/12 21:00 | East Texas A&M v Nicholls State | W | 10-12 |
| NCAAF | 2022/10/29 20:00 | Nicholls State v Lamar | L | 17-24 |
| NCAAF | 2022/10/22 20:00 | McNeese State v Nicholls State | W | 35-40 |
| NCAAF | 2022/10/15 20:00 | Incarnate Word v Nicholls State | L | 49-14 |
| NCAAF | 2022/10/08 23:00 | Nicholls State v Houston Christian | W | 19-17 |
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | L | 33-36 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | L | 52-21 |
| NCAAF | 2022/11/19 20:00 | Tennessee State v East Texas A&M | L | 22-14 |
| NCAAF | 2022/11/12 21:00 | East Texas A&M v Nicholls State | L | 10-12 |
| NCAAF | 2022/11/05 19:00 | Northwestern State v East Texas A&M | L | 41-14 |
| NCAAF | 2022/10/29 19:00 | Incarnate Word v East Texas A&M | L | 35-7 |
| NCAAF | 2022/10/22 19:00 | Houston Christian v East Texas A&M | W | 3-31 |
| NCAAF | 2022/10/16 00:00 | East Texas A&M v McNeese State | W | 40-15 |
| NCAAF | 2022/10/08 21:00 | East Texas A&M v SE Louisiana | W | 31-28 |
| NCAAF | 2022/09/24 23:00 | East Texas A&M v North American Stallions | W | 63-3 |