Stadium: EagleBank Arena
| WNCAAB | 2022/03/01 19:00 | High Point (W) v Charleston Southern (W) | L | 54-34 |
| WNCAAB | 2022/02/26 19:00 | Charleston Southern (W) v UNC Asheville Women | L | 43-63 |
| WNCAAB | 2022/02/23 23:00 | North Carolina A&T (W) v Charleston Southern (W) | L | 76-42 |
| WNCAAB | 2022/02/19 19:00 | Charleston Southern (W) v High Point (W) | L | 50-71 |
| WNCAAB | 2022/02/17 22:30 | High Point (W) v Charleston Southern (W) | L | 69-60 |
| WNCAAB | 2022/02/15 23:00 | Winthrop (W) v Charleston Southern (W) | L | 56-43 |
| WNCAAB | 2022/02/12 19:00 | Charleston Southern (W) v Campbell (W) | L | 52-63 |
| WNCAAB | 2022/02/09 23:00 | Gardner Webb Women v Charleston Southern (W) | L | 90-51 |
| WNCAAB | 2022/03/04 00:30 | George Mason (W) v Fordham (W) | L | 50-66 |
| WNCAAB | 2022/03/02 21:00 | St Louis Women v George Mason (W) | W | 50-65 |
| WNCAAB | 2022/02/26 17:00 | George Mason (W) v St Bonaventure Women | W | 61-50 |
| WNCAAB | 2022/02/24 00:00 | St Louis Women v George Mason (W) | L | 58-35 |
| WNCAAB | 2022/02/19 20:00 | VA Commonwealth Women v George Mason (W) | L | 67-56 |
| WNCAAB | 2022/02/17 00:00 | George Mason (W) v George Washington Women | L | 57-65 |
| WNCAAB | 2022/02/13 20:00 | Saint Joseph's (W) v George Mason (W) | L | 50-45 |
| WNCAAB | 2022/02/11 17:00 | George Mason (W) v Massachusetts (W) | L | 58-87 |