Round: 2
Home Manager: Giannis Dragonakis Away Manager: Leonidas Vokolos
| Greece Play-Offs | 2022/06/11 14:30 | Proodeftiki v Panachaiki | W | 2-1 |
| Greece Gamma Ethniki | 2022/06/05 14:30 | Ilioupoli v Proodeftiki | L | 1-0 |
| Greece Play-Offs | 2022/06/01 14:30 | Pao Rouf v Proodeftiki | W | 0-2 |
| Greece Gamma Ethniki | 2022/05/28 14:00 | Proodeftiki v Iraklis Larisas | W | 4-0 |
| Greece Play-Offs | 2022/05/18 14:00 | Proodeftiki v Makedonikos | D | 0-0 |
| Greece Play-Offs | 2022/05/15 14:00 | Agrotikos Asteras v Proodeftiki | L | 1-0 |
| Greece Amateur Cup | 2022/04/13 13:30 | Hellas Pontion v Proodeftiki | L | 2-1 |
| Greece Gamma Ethniki | 2022/04/10 13:00 | Proodeftiki v Panelefsiniakos | D | 1-1 |
| Greece Super League 2 | 2022/05/01 11:45 | Athens Kallithea v Kissamikos | W | 3-1 |
| Greece Super League 2 | 2022/04/27 12:30 | Diagoras v Athens Kallithea | D | 0-0 |
| Greece Super League 2 | 2022/04/23 11:30 | AEK Athens B v Athens Kallithea | W | 0-3 |
| Greece Super League 2 | 2022/04/17 11:45 | Athens Kallithea v Asteras Vlachioti | W | 5-1 |
| Greece Super League 2 | 2022/04/13 15:00 | Ergotelis v Athens Kallithea | W | 0-2 |
| Greece Super League 2 | 2022/04/10 11:45 | Athens Kallithea v Karaiskakis | W | 4-2 |
| Greece Super League 2 | 2022/04/06 12:00 | Panathinaikos B v Athens Kallithea | D | 0-0 |
| Greece Super League 2 | 2022/04/03 11:45 | Athens Kallithea v Kalamata | D | 0-0 |