[5] DET Red Wings 2-5 FLA Panthers [1] 2021-12-22 03:00
Stadium: Amerant Bank Arena
Home Manager: Jeff Blashill Away Manager: Andrew Brunette
Head to Head
| NHL | 2021/10/29 23:00 | FLA Panthers v DET Red Wings | L | 3-2 |
| NHL | 2021/04/01 23:00 | DET Red Wings v FLA Panthers | L | 2-3 |
| NHL | 2021/03/30 23:00 | DET Red Wings v FLA Panthers | L | 1-4 |
| NHL | 2021/02/20 22:00 | FLA Panthers v DET Red Wings | W | 1-2 |
| NHL | 2021/02/20 00:00 | FLA Panthers v DET Red Wings | L | 7-2 |
| NHL | 2021/02/10 00:00 | DET Red Wings v FLA Panthers | L | 1-2 |
| NHL | 2021/02/07 20:00 | DET Red Wings v FLA Panthers | W | 4-1 |
| NHL | 2021/01/31 22:00 | FLA Panthers v DET Red Wings | L | 3-2 |
Home History
| NHL | 2021/12/19 01:00 | NJ Devils v DET Red Wings | W | 2-5 |
| NHL | 2021/12/17 00:00 | DET Red Wings v CAR Hurricanes | L | 3-5 |
| NHL | 2021/12/15 00:30 | NY Islanders v DET Red Wings | W | 1-2 |
| NHL | 2021/12/11 02:00 | DET Red Wings v COL Avalanche | L | 3-7 |
| NHL | 2021/12/10 01:00 | DET Red Wings v STL Blues | L | 2-6 |
| NHL | 2021/12/08 00:00 | NSH Predators v DET Red Wings | L | 5-2 |
| NHL | 2021/12/05 00:00 | NY Islanders v DET Red Wings | W | 3-4 |
| NHL | 2021/12/02 00:30 | SEA Kraken v DET Red Wings | W | 3-4 |
Away History
| NHL | 2021/12/17 00:00 | LA Kings v FLA Panthers | L | 4-1 |
| NHL | 2021/12/15 00:00 | OTT Senators v FLA Panthers | L | 8-2 |
| NHL | 2021/12/13 01:00 | FLA Panthers v COL Avalanche | L | 2-3 |
| NHL | 2021/12/11 02:00 | FLA Panthers v ARZ Coyotes | W | 3-1 |
| NHL | 2021/12/08 01:00 | FLA Panthers v STL Blues | L | 3-4 |
| NHL | 2021/12/04 18:00 | STL Blues v FLA Panthers | W | 3-4 |
| NHL | 2021/12/03 00:00 | BUF Sabres v FLA Panthers | W | 4-7 |
| NHL | 2021/12/01 00:00 | WAS Capitals v FLA Panthers | W | 4-5 |