Stadium: Court 4 Round: 25 Ground: Hardcourt outdoor
| ITF W15 Cancun | 2021/09/19 17:00 | Natsuho Arakawa v Esther Vyrlan | 6-7,6-4,10-4 |
| ITF W25 Daytona Beach | 2021/11/08 16:00 | Maria Jose Portillo Ramirez v Lexington Reed | 6-1,6-3 |
| ITF W25 Orlando | 2021/11/06 15:30 | Maria Jose Portillo Ramirez v Amina Anshba | 1-6,6-7 |
| ITF W25 Orlando | 2021/11/04 15:00 | Fernanda Contreras Gomez v Maria Jose Portillo Ramirez | 7-5,6-7,1-6 |
| ITF W25 Orlando | 2021/11/03 19:05 | Maria Jose Portillo Ramirez v Chieh-Yu Hsu | 6-2,6-7,6-1 |
| ITF W25 Orlando | 2021/11/02 13:55 | Maria Jose Portillo Ramirez v Katja Wiersholm | 6-1,6-3 |
| ITF W25 Orlando | 2021/11/01 17:00 | Maria Jose Portillo Ramirez v Maria Kononova | 6-4,6-1 |
| ITF W25 Austin | 2021/10/26 17:40 | Maria Jose Portillo Ramirez v Liga Dekmeijere | 6-2,4-6,7-10 |
| ITF W25 Austin | 2021/10/25 17:00 | Maria Jose Portillo Ramirez v Rachel Gailis | 6-4,7-5 |