Stadium: Benito Villamarin Round: 21
Referee: Jose Maria Sanchez Martinez Home Manager: Manuel Pellegrini Away Manager: Jose Luis Mendilibar
| Spain La Liga | 2021/10/18 17:00 | CD Alaves v Real Betis | W | 0-1 |
| Spain La Liga | 2021/03/08 20:00 | Real Betis v CD Alaves | W | 3-2 |
| Spain La Liga | 2020/09/13 12:00 | CD Alaves v Real Betis | W | 0-1 |
| Spain La Liga | 2020/07/16 19:00 | Real Betis v CD Alaves | L | 1-2 |
| Spain La Liga | 2020/01/05 15:00 | CD Alaves v Real Betis | D | 1-1 |
| Spain La Liga | 2019/02/17 19:45 | Real Betis v CD Alaves | D | 1-1 |
| Spain La Liga | 2018/08/25 16:15 | CD Alaves v Real Betis | D | 0-0 |
| Spain La Liga | 2018/03/12 20:00 | CD Alaves v Real Betis | W | 1-3 |
| Spain La Liga | 2022/01/02 17:30 | Real Betis v Celta Vigo | L | 0-2 |
| Spain La Liga | 2021/12/19 15:15 | Athletic Bilbao v Real Betis | L | 3-2 |
| Spain Copa del Rey | 2021/12/16 18:00 | CF Talavera v Real Betis | D | 2-2 |
| Spain La Liga | 2021/12/12 17:30 | Real Betis v Real Sociedad | W | 4-0 |
| UEFA Europa League | 2021/12/09 20:00 | Celtic v Real Betis | L | 3-2 |
| Spain La Liga | 2021/12/04 15:15 | Barcelona v Real Betis | W | 0-1 |
| Spain Copa del Rey | 2021/12/01 20:00 | CFI Alicante v Real Betis | W | 0-4 |
| Spain La Liga | 2021/11/28 13:00 | Real Betis v Levante | W | 3-1 |
| Spain La Liga | 2022/01/02 17:30 | CD Alaves v Real Sociedad | D | 1-1 |
| Spain La Liga | 2021/12/21 18:00 | Villarreal v CD Alaves | L | 5-2 |
| Spain La Liga | 2021/12/18 13:00 | Rayo Vallecano v CD Alaves | L | 2-0 |
| Spain Copa del Rey | 2021/12/14 20:00 | Linares Deportivo v CD Alaves | L | 2-1 |
| Spain La Liga | 2021/12/11 15:15 | CD Alaves v Getafe | D | 1-1 |
| Spain La Liga | 2021/12/03 20:00 | Granada v CD Alaves | L | 2-1 |
| Spain Copa del Rey | 2021/11/30 18:00 | Unami CP v CD Alaves | W | 0-3 |
| Spain La Liga | 2021/11/27 13:00 | CD Alaves v Celta Vigo | L | 1-2 |