Round: 9
Home Manager: Giannis Vonortas Away Manager: Nikolaos Papadopoulos
| Greece Super League 2 | 2021/12/04 15:00 | Ergotelis v Panathinaikos B | L | 1-0 |
| Greece Super League 2 | 2021/11/27 12:45 | Panathinaikos B v Karaiskakis | D | 2-2 |
| Greece Super League 2 | 2021/11/20 13:00 | Kalamata v Panathinaikos B | W | 1-2 |
| Greece Super League 2 | 2021/11/14 13:00 | Panathinaikos B v AEK Athens B | L | 0-2 |
| Greece Super League 2 | 2021/11/07 13:00 | Kifisias FC v Panathinaikos B | L | 2-0 |
| Greece Super League 2 | 2021/11/28 12:45 | Episkopi FC v Chania FC | D | 1-1 |
| Greece Super League 2 | 2021/11/24 13:00 | Chania FC v Rhodos | D | 2-2 |
| Greece Super League 2 | 2021/11/20 13:00 | Levadiakos v Chania FC | D | 1-1 |
| Greece Super League 2 | 2021/11/14 13:00 | Chania FC v Irodotos | D | 0-0 |
| Greece Super League 2 | 2021/11/07 13:00 | Egaleo v Chania FC | D | 1-1 |
| Greece Cup | 2021/09/29 13:00 | Egaleo v Chania FC | L | 2-1 |
| Europe Friendlies | 2021/09/11 15:00 | Ergotelis v Chania FC | D | 1-1 |
| Greece Super League 2 | 2021/05/16 11:45 | Levadiakos v Chania FC | L | 3-0 |