Stadium: Hart Center Arena
Home Manager: Melissa D'Amico Away Manager: Maureen Magarity
| WNCAAB | 2021/02/21 19:00 | Holy Cross (W) v Boston U (W) | L | 60-52 |
| WNCAAB | 2021/02/20 18:00 | Holy Cross (W) v Boston U (W) | W | 58-70 |
| WNCAAB | 2021/02/17 23:00 | Holy Cross (W) v Boston U (W) | W | 53-71 |
| WNCAAB | 2021/01/05 19:00 | Boston U (W) v Holy Cross (W) | W | 72-56 |
| WNCAAB | 2021/01/04 19:00 | Boston U (W) v Holy Cross (W) | W | 76-54 |
| WNCAAB | 2020/02/08 18:05 | Holy Cross (W) v Boston U (W) | W | 51-62 |
| WNCAAB | 2020/01/25 21:00 | Boston U (W) v Holy Cross (W) | W | 76-70 |
| WNCAAB | 2019/03/11 23:00 | Boston U (W) v Holy Cross (W) | L | 70-72 |
| WNCAAB | 2022/02/05 19:00 | Lehigh (W) v Boston U (W) | L | 68-65 |
| WNCAAB | 2022/02/02 23:00 | Boston U (W) v Bucknell Women | W | 67-58 |
| WNCAAB | 2022/01/29 19:00 | Boston U (W) v Colgate (W) | W | 59-45 |
| WNCAAB | 2022/01/26 23:00 | Lafayette (W) v Boston U (W) | W | 57-67 |
| WNCAAB | 2022/01/22 19:00 | Boston U (W) v Lehigh (W) | L | 67-79 |
| WNCAAB | 2022/01/19 23:00 | Loyola Maryland (W) v Boston U (W) | W | 47-65 |
| WNCAAB | 2022/01/15 18:00 | Boston U (W) v Navy (W) | W | 74-63 |
| WNCAAB | 2022/01/12 23:00 | Army (W) v Boston U (W) | W | 56-64 |
| WNCAAB | 2022/02/05 17:00 | Army (W) v Holy Cross (W) | W | 54-74 |
| WNCAAB | 2022/02/03 23:00 | Holy Cross (W) v Lafayette (W) | W | 59-50 |
| WNCAAB | 2022/01/28 23:00 | Holy Cross (W) v Lehigh (W) | L | 61-67 |
| WNCAAB | 2022/01/26 22:00 | American (W) v Holy Cross (W) | W | 44-55 |
| WNCAAB | 2022/01/22 19:00 | Holy Cross (W) v Bucknell Women | W | 63-62 |
| WNCAAB | 2022/01/19 23:00 | Lafayette (W) v Holy Cross (W) | W | 57-63 |
| WNCAAB | 2022/01/17 22:00 | Loyola Maryland (W) v Holy Cross (W) | W | 48-63 |
| WNCAAB | 2022/01/15 17:00 | Colgate (W) v Holy Cross (W) | W | 57-62 |