Stadium: James H. Hilton Coliseum
Home Manager: Aaron Johnston Away Manager: Bill Fennelly
| WNCAAB | 2021/11/10 00:00 | Wisc Green Bay (W) v South Dakota State (W) | W | 49-70 |
| WNCAAB | 2021/03/21 21:30 | South Dakota State (W) v Syracuse (W) | L | 55-72 |
| WNCAAB | 2021/03/06 17:45 | Nebraska Omaha Women v South Dakota State (W) | L | 52-40 |
| WNCAAB | 2021/02/27 23:00 | South Dakota State (W) v UMKC Women | W | 72-66 |
| WNCAAB | 2021/02/26 23:00 | UMKC Women v South Dakota State (W) | W | 53-73 |
| WNCAAB | 2021/02/20 23:00 | North Dakota State (W) v South Dakota State (W) | W | 60-69 |
| WNCAAB | 2021/02/19 23:00 | South Dakota State (W) v North Dakota State (W) | W | 86-78 |
| WNCAAB | 2021/02/14 19:00 | South Dakota State (W) v Oral Roberts (W) | W | 73-61 |
| WNCAAB | 2021/11/09 17:00 | Nebraska Omaha Women v Iowa State (W) | W | 38-65 |
| WNCAAB | 2021/03/24 23:00 | Iowa State (W) v Texas A&M (W) | L | 82-84 |
| WNCAAB | 2021/03/22 22:00 | Michigan State (W) v Iowa State (W) | W | 75-79 |
| WNCAAB | 2021/03/12 16:30 | Texas (W) v Iowa State (W) | L | 84-82 |
| WNCAAB | 2021/03/04 00:30 | Kansas (W) v Iowa State (W) | W | 53-83 |
| WNCAAB | 2021/02/25 00:30 | West Virginia (W) v Iowa State (W) | W | 68-85 |
| WNCAAB | 2021/02/20 19:00 | Iowa State (W) v Oklahoma State (W) | L | 73-80 |
| WNCAAB | 2021/02/18 01:00 | Kansas (W) v Iowa State (W) | W | 82-84 |