Stadium: United Center
Home Manager: John Hynes Away Manager: Derek King
| NHL | 2021/11/08 00:00 | NSH Predators v CHI Blackhawks | L | 1-2 |
| NHL | 2021/04/24 00:00 | NSH Predators v CHI Blackhawks | W | 3-1 |
| NHL | 2021/04/21 23:00 | NSH Predators v CHI Blackhawks | L | 4-5 |
| NHL | 2021/04/20 00:00 | CHI Blackhawks v NSH Predators | W | 2-5 |
| NHL | 2021/04/03 19:00 | CHI Blackhawks v NSH Predators | W | 0-3 |
| NHL | 2021/03/29 00:00 | NSH Predators v CHI Blackhawks | W | 3-2 |
| NHL | 2021/03/28 00:00 | NSH Predators v CHI Blackhawks | W | 3-1 |
| NHL | 2021/01/28 00:30 | CHI Blackhawks v NSH Predators | W | 1-2 |
| NHL | 2021/11/08 00:00 | NSH Predators v CHI Blackhawks | L | 1-2 |
| NHL | 2021/11/06 02:00 | NSH Predators v VAN Canucks | W | 3-2 |
| NHL | 2021/11/04 00:30 | NSH Predators v EDM Oilers | L | 2-5 |
| NHL | 2021/11/03 01:00 | NSH Predators v CGY Flames | W | 3-2 |
| NHL | 2021/10/30 17:30 | NY Islanders v NSH Predators | W | 2-3 |
| NHL | 2021/10/27 00:30 | SJ Sharks v NSH Predators | W | 1-3 |
| NHL | 2021/10/24 22:00 | NSH Predators v MIN Wild | W | 5-2 |
| NHL | 2021/10/23 23:00 | NSH Predators v WPG Jets | L | 4-6 |
| NHL | 2021/11/08 00:00 | NSH Predators v CHI Blackhawks | W | 1-2 |
| NHL | 2021/11/06 00:00 | CHI Blackhawks v WPG Jets | L | 1-5 |
| NHL | 2021/11/04 00:30 | CAR Hurricanes v CHI Blackhawks | L | 4-3 |
| NHL | 2021/11/02 00:00 | OTT Senators v CHI Blackhawks | W | 1-5 |
| NHL | 2021/10/31 00:00 | CHI Blackhawks v STL Blues | L | 0-1 |
| NHL | 2021/10/29 23:00 | CHI Blackhawks v CAR Hurricanes | L | 3-6 |
| NHL | 2021/10/27 23:30 | TOR Maple Leafs v CHI Blackhawks | L | 3-2 |
| NHL | 2021/10/24 23:00 | DET Red Wings v CHI Blackhawks | L | 6-3 |