[27] Sothon/Trinkajee 2-4 BUF Sabres [19] 2019-08-26 22:00
Stadium: KeyBank Center
Home Manager: Away Manager: Ralph Krueger
Head to Head
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | L | 2-5 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | W | 0-4 |
| NHL | 2018/11/03 18:00 | OTT Senators v BUF Sabres | L | 2-9 |
| NHL | 2018/11/01 23:30 | BUF Sabres v OTT Senators | W | 2-4 |
| NHL | 2018/04/04 23:30 | OTT Senators v BUF Sabres | W | 4-2 |
| NHL | 2018/03/09 00:30 | BUF Sabres v OTT Senators | L | 4-3 |
| NHL | 2018/02/16 00:30 | BUF Sabres v OTT Senators | W | 2-3 |
| NHL | 2017/12/13 00:00 | OTT Senators v BUF Sabres | L | 2-3 |
Home History
| NHL | 2019/04/06 23:00 | CLB Blue Jackets v OTT Senators | L | 6-2 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | L | 2-5 |
| NHL | 2019/04/03 23:30 | OTT Senators v NY Rangers | W | 4-1 |
| NHL | 2019/04/01 23:30 | TB Lightning v OTT Senators | L | 5-2 |
| NHL | 2019/03/30 23:00 | TOR Maple Leafs v OTT Senators | W | 2-4 |
| NHL | 2019/03/28 23:30 | FLA Panthers v OTT Senators | L | 5-2 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | W | 0-4 |
| NHL | 2019/03/23 20:00 | OTT Senators v EDM Oilers | W | 4-3 |
Away History
| NHL | 2019/04/06 23:00 | BUF Sabres v DET Red Wings | W | 7-1 |
| NHL | 2019/04/04 23:00 | OTT Senators v BUF Sabres | W | 2-5 |
| NHL | 2019/04/02 23:00 | NSH Predators v BUF Sabres | L | 3-2 |
| NHL | 2019/03/31 22:00 | CLB Blue Jackets v BUF Sabres | L | 4-0 |
| NHL | 2019/03/30 23:00 | BUF Sabres v NY Islanders | L | 1-5 |
| NHL | 2019/03/28 23:00 | DET Red Wings v BUF Sabres | L | 5-4 |
| NHL | 2019/03/26 23:30 | BUF Sabres v OTT Senators | L | 0-4 |
| NHL | 2019/03/25 23:00 | BUF Sabres v NJ Devils | L | 1-3 |