Stadium: Caesars Superdome Round: 14
Home Manager: Kyle Shanahan Away Manager: Sean Payton
| 1 | 2 | H | 3 | 4 | F |
|---|---|---|---|---|---|
| 7 | 21 | 28 | 7 | 13 | 48 |
| 13 | 14 | 27 | 6 | 13 | 46 |
| SF 49ers | Borella/ Kivattsev |
| Lineup | |
|---|---|
| 57 - Left back - Dre Greenlaw | Dwayne Washington - Right back - 27 |
| 92 - DE - Jeremiah Valoaga | Erik McCoy - OL - 78 |
| 22 - Right back - Matt Breida | Mario Edwards Jr. - DE - 97 |
| 69 - OT - Mike McGlinchey | P.J. Williams - DB - 26 |
| 67 - OT - Justin Skule | Tre'Quan Smith - WR - 10 |
| 3 - Pivot - Mitch Wishnowsky | Malcom Brown - DT - 90 |
| 97 - DE - Nick Bosa | Stephone Anthony - OLB - 58 |
| 1 - WR - Deebo Samuel | Terron Armstead - OT - 72 |
| 41 - Center back - Emmanuel Moseley | Demario Davis - Left back - 56 |
| 44 - FB - Kyle Juszczyk | Josh Hill - TE - 89 |
| 36 - SAF - Marcell Harris | J.T. Gray - DB - 48 |
| 13 - WR - Richie James | Michael Ola - OT - 70 |
| 82 - TE - Ross Dwelley | Nick Easton - Center - 62 |
| 51 - Left back - Azeez Al-Shaair | David Onyemata - DT - 93 |
| 33 - DB - Tarvarius Moore | Ryan Ramczyk - OT - 71 |
| 54 - Left back - Fred Warner | Wil Lutz - K - 3 |
| 32 - Center back - D.J. Reed | Carl Granderson - DE - 96 |
| 84 - WR - Kendrick Bourne | Vonn Bell - SAF - 24 |
| 86 - LS - Kyle Nelson | Eli Apple - Center back - 25 |
| 9 - K - Robbie Gould | Sheldon Rankins - DT - 98 |
| 17 - WR - Emmanuel Sanders | Marshon Lattimore - Center back - 23 |
| 74 - OT - Joe Staley | Alvin Kamara - Right back - 41 |
| 38 - SS - Antone Exum | Marcus Williams - SAF - 43 |
| 63 - OG - Ben Garland | Larry Warford - OG - 67 |
| 20 - DB - Jimmie Ward | Teddy Bridgewater - QB - 5 |
| 25 - Center back - Richard Sherman | Ethan Greenidge - OL - 73 |
| 68 - OG - Mike Person | Marcus Davenport - DE - 92 |
| 10 - QB - Jimmy Garoppolo | Latavius Murray - Right back - 28 |
| 24 - Center back - K'Waun Williams | Trey Hendrickson - DE - 91 |
| 88 - TE - Garrett Celek | Johnson Bademosi - Center back - 29 |
| 91 - DE - Arik Armstead | Chauncey Gardner-Johnson - SAF - 22 |
| 75 - OG - Laken Tomlinson | Deonte Harty - WR - 11 |
| 26 - Right back - Tevin Coleman | Patrick Omameh - OL - 60 |
| 60 - OL - Daniel Brunskill | Jared Cook - TE - 87 |
| 4 - QB - Nick Mullens | Craig Robertson - OLB - 52 |
| 47 - Left back - Elijah Lee | Shy Tuttle - DT - 99 |
| 85 - TE - George Kittle | Ted Ginn - WR - 19 |
| 93 - DT - D.J. Jones | Drew Brees - QB - 9 |
| 23 - Center back - Ahkello Witherspoon | Taysom Hill - TE - 7 |
| 94 - DT - Solomon Thomas | Manti Te'o - MLB - 51 |
| 99 - DT - DeForest Buckner | Cameron Jordan - DE - 94 |
| 96 - DT - Sheldon Day | Thomas Morstead - Pivot - 6 |
| 55 - DE - Dee Ford | Justin Hardee - Center back - 34 |
| 53 - OLB - Mark Nzeocha | Krishawn Hogan - WR - 81 |
| 31 - Right back - Raheem Mostert | Zach Wood - LS - 49 |
| 58 - Center - Weston Richburg | Michael Thomas - WR - 13 |
| Substitutes | |